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      New Product - Gastric Function Test - Pepsinogen I/II(PGI/II

      Published: 2019-01-29| Size:L M S|

      1.Pepsinogen

      Pepsinogen (PG) is the precursor of pepsin secreted by the stomach and involved in digestion. Generally, 1% of PG can enter the blood circulation through the gastric mucosa, which can be divided into two subtypes: PGI and PGII


      Serum pepsinogen can accurately show the state and function of gastric mucosa


      Pepsinogen I is secreted by the main cells and cervical mucus cells of the gastric fundus gland


      Pepsinogen II can be produced in the pyloric and duodenal glands in addition to the secretion of the host cells and cervical mucus cells


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      2.Biological Function Of Pepsinogen

      With the development of gastric disease, PGI in serum first increases, then decreases, and then increases, and then maintains a higher level. Thus, the abnormal PGI / PGII ratio of PGI and PGII will indicate the different course of gastric disease and become the primary screening index and monitoring index of treatment for gastric diseases


      3.Main Clinical Significance

      A. Early screening of gastric cancer

      B. Screening of gastric ulcer, atrophic gastritis and HP infection

      C. Evaluation of therapeutic effect of Helicobacter pylori (HP)

      D. Criteria for recurrence and cure of peptic ulcer

      E. Criteria of recurrence after gastrectomy

      F. Dynamic examination of gastric mucosa function


      4.Who is suitable for PGI / PGII

      Helicobacter pylori infection

      Male, especially over 2025kg

      50 to 80

      Salt, pickled vegetables, bacon and fish

      Smoke

      Old stomach with gastric operation and polyp

      Family cancer, family history of gastric cancer

      Pernicious anemia

      Type A blood

      Long term working with a lot of smoke, asbestos and nickel ring


      5.Reference Norm

      PGI normal reference value range is 70-200ng / ml

      PGII normal reference value range is 0-15ng / ml

      PGI/ PGII7.5


      Applicable Platform


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